BVES antibody (AA 241-360)

Catalog No. ABIN7145640

The Rabbit Polyclonal anti-BVES antibody has been validated for ELISA and IF. It is suitable to detect BVES in samples from Human.

Quick Overview for BVES antibody (AA 241-360) (ABIN7145640)

Target: BVES (Blood Vessel Epicardial Substance (BVES))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BVES antibody is un-conjugated

Application: ELISA, Immunofluorescence (IF)

Product Details anti-BVES Antibody

Binding Specificity: AA 241-360

Purpose: BVES Antibody

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Blood vessel epicardial substance protein (241-360AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for BVES

Target: BVES (Blood Vessel Epicardial Substance (BVES))

Alternative Name: BVES

Background:

Background: Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells (PubMed:16188940). Plays a role in VAMP3-mediated vesicular transport and recycling of different receptor molecules through its interaction with VAMP3. Plays a role in the regulation of cell shape and movement by modulating the Rho-family GTPase activity through its interaction with ARHGEF25/GEFT. Induces primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)-independent manner. Also involved in striated muscle regeneration and repair and in the regulation of cell spreading (By similarity). Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density (PubMed:26642364). Is also a caveolae-associated protein important for the preservation of caveolae structural and functional integrity as well as for heart protection against ischemia injury.

Aliases: Blood vessel epicardial substance antibody, Bves antibody, hBVES antibody, MGC42413 antibody, POP 1 antibody, POP1 antibody, POPD1_HUMAN antibody, POPDC 1 antibody, POPDC1 antibody, Popeye domain containing 1 antibody, Popeye domain containing protein 1 antibody, Popeye domain-containing protein 1 antibody, Popeye protein 1 antibody

UniProt: Q8NE79